منابع مشابه
Arylsulfatase K, a novel lysosomal sulfatase.
The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation. The loss of sulfatase activity has been linked to severe pathophysiological conditions such as lysosoma...
متن کاملStructure of human saposin A at lysosomal pH
The saposins are essential cofactors for the normal lysosomal degradation of complex glycosphingolipids by acid hydrolase enzymes; defects in either saposin or hydrolase function lead to severe metabolic diseases. Saposin A (SapA) activates the enzyme β-galactocerebrosidase (GALC), which catalyzes the breakdown of β-D-galactocerebroside, the principal lipid component of myelin. SapA is known to...
متن کاملStructure of the human gene for lysosomal di-N-acetylchitobiase.
Chitobiase is a lysosomal glycosidase that acts during the ordered degradation of asparagine-linked glycoproteins to cleave the core chitobiose unit at its reducing end. Human chitobiase is expressed in significant amounts, while bovine chitobiase is produced at extremely low levels. To begin to understand this species-dependent expression, we determined the gene structure of human chitobiase. ...
متن کاملThe Role of Mathematics on Human Structure
This book explores the mathematical view of selected body systems and organs and as claimed by its author, “it has an objective to facilitate modern treatment with mathematical precision.”The author, Dr. Adhikari has PhD in mathematics and is the Head of the Institution and Department of Mathematics, Ghusuri Uchcha Madhyamic Vidyalaya, West Bengal, India. The motivation of the author in writing...
متن کاملLysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein
The biochemistry and intracellular transit of an integral membrane glycoprotein of chicken fibroblast lysosomes were studied with monoclonal antibody techniques. The glycoprotein had an apparent molecular weight of 95,000-105,000. Structural analysis involving metabolic labeling with [35S]methionine and cleavage with glycosidases revealed the presence of numerous oligosaccharide chains N-linked...
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ژورنال
عنوان ژورنال: Structure
سال: 1997
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(97)00185-8